Pharmacological Options Beyond Proton Pump Inhibitors in Children with Gastroesophageal Reflux Disease
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چکیده
Pharmacological treatment of gastroesophageal reflux (GER) disease is mostly based on acid control. However, different molecules have been proposed both for patients with persisting symptoms and to limit adverse effects of proton pump inhibitors (PPI). This paper focuses on other acid inhibitors, alginate, prokinetics, drug acting on lower esophageal sphincter and esophageal hypersensitivity. Mechanism of action, indications, efficacy, limits and recent advances are reported. Pediatric data and possible adverse effects are also considered.
منابع مشابه
comparison of the effect of omeprazole,es omeprazole and lanzoprazole on treatment of gastroesophageal reflux disease referred children aged 2 to 24 months to shahid- mofatteh clinic of yasuj-2015
Background and objective:Gastroesophageal reflux is one of the most common esophageal disordersat all age groups, especially in children, due to the transient slackness of sphincter of the lower esophagus, which results in impairment in the quality of life of the infant.Various studies have shown that proton pump inhibitors have a beneficial effect on the treatment of gastroesophageal reflux di...
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